General Introduction
一般介紹

Chan Sui Yin Agnes is currently a Professor at the Department of Psychology of the Chinese University of Hong Kong and the Director of the Research Center for Neuropsychological Well-Being.  She obtained a doctoral degree in 1995, majoring in clinical neuropsychology from the University of California at San Diego (UCSD).  Her research interests include memory problems associated with mild cognitive impairment, frontal dysfunction associated with various brain disorders (e.g., dementia, autism), and innovative interventions for improving cognitive functions.  She has obtained over HKD 23 million (21 million as a primary investigator) external funding to conduct my research.  She has published over one hundred journal articles and about ten books.  She has been published in Top-ranking journals including Nature, and BBC, ABC, and New York Times reported her research. She was appointed to several honorary positions, including adjunct faculty at the University of Michigan at Ann Arbor and Consultant to the Alzheimer’s Disease Research Center at UCSD.  She was an associate editor of the journal Neuropsychology and on the editorial board of the International Journal of Neuropsychological Society.  She is the author of a commonly used clinical assessment in Hong Kong, namely the Hong Kong List Learning Test.

陳瑞燕現為香港中文大學心理學系教授及心智健康研究中心主任。 她於1995年獲得博士學位,主修加州大學聖地牙哥分校(UCSD)的臨床神經心理學。 她的研究興趣包括與與各種腦部疾病相關的額葉功能障礙(例如腦退化、自閉症)、與輕度認知障礙相關的記憶問題、改善認知功能的創新干預方法。 她 已 獲得超過2300萬港元(作為主要研究員2100萬)的外部資金來進行我的研究。 她發表了一百多篇期刊文章和大約十本書。 她曾在頂級期刊,包括 《自然》,上發表過文章 ,英國廣播公司(BBC)、美國廣播公司(ABC)和《紐約時報》也報導了她的研究。她被任命為多個榮譽職位,包括密歇根大學安亞伯分校的兼職教師和加州大學聖地牙哥分校阿爾茨海默病研究中心的顧問。 她曾是《神經心理學》學術期刊的副主編和國際神經心理學會學術期刊的編輯委員會的成員。 她是香港一個常用臨床評估,香港文字記憶測試,的作者。

Research Statement

研究描述

 

One of my research interests is to study ways to optimize brain function, that is, how to keep or improve brain function at the best performance level.  These research findings are applicable to clinical intervention, education, and human resource in business.   That is, optimizing the brain functions of patients with brain disorders can improve their cognitive abilities and emotion, optimizing the brain function of children can improve their learning and academic performance, and optimizing the brain function of working forces in the company can improve productivity and creativity of the company.  This research interest led me to study lifestyle medicine and brain stimulation.  I have developed the Chanwuyi lifestyle medicine program and have conducted research to evaluate its impact on cognitive and psychological functions (Chan et al., 2009, 2011, 0212, 2013, 2014, 2017, 2018, 2020, 2021). Our research findings suggest that this program positively improves the memory, psychological and physical health of older adults, adults, and children.  The Chanwuyi lifestyle medicine program was certified by the American College of Lifestyle Medicine in 2021.  My recent interest has extended to investigate the impact of photobiomodulation on improving the memory of older adults with mild cognitive impairment (Chan et al., 2019, 2021, 2021) and to study the eye-tracking technology on improving frontal lobe function (Lee et al., 2020, 2021),  The results so far are encouraging. 

 

I have been interested in the early detection of dementia for over 20 years.  One early approach I had adopted in studying this topic was modelling the semantic network of patients with Alzheimer’s disease. Using multidimensional scaling methods and pathfinder analyses, I delineated the possible connection between patients’ cognitive deterioration and pathological neural changes (Chan et al., 1993, 1993, 1995, 1995, 1997, 1998, 1998, 2001).   I received the Rennick Award in 1992 and the Edwin Newman Award in 1994 for this line of research.  Recently, we have investigated the potential of functional near-infrared spectroscopy (fNIRS) as a possible biomarker for early detection of mild cognitive impairment (Yeung et al., 2016a and 2016b, Yeung & Chan, 2020, Yeung & Chan, 2021) and the hemodynamic changes associated with memory tasks seems to be a potential approach.

 

I have been interested in studying memory and the brain.    Besides studying the memory of patients with Alzheimer’s disease, I have studied patients with unilateral or bilateral temporal lobe damage resulting from radiotherapy for nasopharyngeal carcinoma (Chan et al., 2004; Cheung et al., 2000, 2003), Our findings showed that radiotherapy may cause the development of edema or cysts in some patients, thereby impairing their cognitive functions. We then explored possible ways to improve the cognitive functions of this group of patients and found that patients who took Vitamin E for one year demonstrated significant memory improvements (Chan et al., 2004). 

  

I am also interested in investigating the effects of early-life experience on the development of cognitive functions and their relation to neuroanatomical changes. For example, based on the finding that musicians tended to have enlarged left, but not right, planum temporales when compared with nonmusicians, my research team and I proposed and found that individuals with music training tended to have better verbal, but not visual, memory than those without such training (Chan et al., 1998, Ho et al., 2003). The study, published in Nature, provided suggestive evidence that early-life experience may systematically affect cognitive functions through neuroanatomical changes.  Along this line of research interest, I have studied the behavioral problem of children with autistic spectrum disorder (ASD) from the neuropsychological perspective.  We have utilized EEG (Chan et al., 2011, Han et al., 2013, Yeung et al., 2014, Yeung et al., 2016, Han et al., 2017), and fNIRS (Yeung et al., 2019, Krishnamurthy et al., 2020) to examine the prefrontal cortex and the inhibitory control of ASD children.  We also examine some interventions to improve the behavioral problems of children with special educational needed, including the lifestyle medicine approach and eye-tracking computerized training (Lee et al., 2021).   

 

I have obtained over HKD 23 million (21 million as a primary investigator) external funding to conduct my research.  I have published over one hundred journal articles and about ten books.  I have published articles in internationally respected journals such as Nature, Scientific Reports, and Neuropsychology.  My highest citation is 933I which I am the corresponding author, I published 66 Q1 papers and 87 first or corresponding author papers.  I was awarded the Early Career Award in Neuropsychology from the American Psychological Association-Division 40 in 2004. In addition, I was appointed to several honorary positions by respected overseas institutions, including San Diego State University, the University of California at San Diego, and the University of Michigan at Ann Arbor.  Furthermore, I served as an associate editor or editorial board member in several scientific journals including the Journal of International Neuropsychological Society, Neuropsychology, Journal of Alzheimer’s Disease, Journal of Clinical Medicine, and Lifestyle Medicine. Besides, I have been invited to conduct workshops and seminars internationally including at Harvard University and the University of Michigan at Ann Arbor.

 

Apart from research, I am also interested to transfer my knowledge to society.  I developed the Hong Kong List Learning Test (HKLLT) in 1997, an ecological validated verbal memory test in Hong Kong.  The HKLLT has been made available to the clinical profession and academics since 2006 and has been used by most public hospitals and government institutions and some research settings for over 15 years.   I have written nine books for the general public and established a YouTube channel (the highest view video is 70,000).  I founded the Hong Kong Neuropsychological Association in 1998 for promoting Neuropsychology in Hong Kong and Asia.   In addition, I established the Pro-talent Association Ltd. in 2003 with start-up funding support from the Chinese University of Hong Kong to make our research output available to children with special education needed. 

 

 

我的研究興趣之一是研究優化大腦功能的方法,即如何將大腦功能保持在最佳性能水準或改善。 這些研究結果適用於臨床干預,教育和商業中的人力資源。  也就是說,刺激腦部疾病患者的大腦功能可以提高他們的認知能力和情緒,優化兒童的大腦功能可以提高他們的學習和學業成績,優化公司工作人力資源的大腦功能可以提高公司的生產力和創造力。 這研究興趣促使我學習生活方式醫學和大腦刺激。 我開發了禪武醫生活方式醫學計劃,並進行了研究以評估其對認知和心理功能的影響(Chan等人,2009,2011,0212,2013,2014,2017,2018,2020,2021)。我們的研究結果表明,該計劃可以積極改善老年人,成人和兒童的記憶力,心理和身體健康。 禪武醫生活方式醫學專案於2021年獲得美國生活方式醫學院認證。 我最近的興趣已經擴展到研究光生物調節對改善輕度認知障礙老年人記憶力的影響(Chan等人,2019,2021,2021),並研究眼動追蹤技術對改善額葉功能的影響(Lee等人,2020,2021),到目前為止,結果令人鼓舞。

我一直對癡呆症的早期發現感興趣, 已經20年了。  我在研究這個主題時採用的一種早期方法是對阿爾茨海默病患者的語義網路進行建模。使用多維縮放方法和探路者分析,我描繪了患者認知惡化與病理神經變化之間可能存在的聯繫(Chan等人,1993,1993,1995,1995,1997,1998,1998,2001)。  我於1992年獲得了倫尼克獎,並於1994年獲得了埃德溫·紐曼獎。 最近,我們研究了功能性近紅外光譜(fNIRS)作為早期檢測輕度認知障礙的可能生物標誌物的潛力(Yeung等人,2016a和2016b,Yeung&Chan,2020,Yeung&Chan,2021),與記憶任務相關的血液動力學變化似乎是一種可能發展的方法。

 

 

我一直對研究記憶和大腦感興趣。  除了研究阿爾茨海默病患者的記憶外,我還研究了鼻咽癌放療引起的單側或雙側顳葉損傷的患者(Chan等人,2004;Cheung等人,2000,2003),我們的研究結果表明,放射治療可能導致某些患者出現水腫或囊腫,從而損害他們的認知功能。然後,我們探索了改善這組患者的認知功能的可能方法,發現服用維生素E一年的患者表現出顯著的記憶改善(Chan等人,2004)。

 

 

我還有興趣研究早期生活經驗對認知功能發展的影響及其與神經解剖學變化的關係。例如,基於與非音樂家相比,音樂家傾向於向左而不是向右擴大平面顳的發現,我和我的研究小組提出並發現,受過音樂訓練的個體往往比沒有受過這種訓練的人具有更好的口頭記憶力,但不是視覺記憶力(Chan等人,1998,Ho等人, 這項發表在《自然》雜誌上的研究提供了暗示性的證據,表明早期生活經驗可能通過神經解剖學變化系統地影響認知功能。 沿著這一研究興趣,我從神經心理學的角度研究了自閉症譜系障礙(ASD)兒童的行為問題。 我們利用腦電圖(Chan et al., 2011, Han et al., 2013, Yeung et al., 2014, Yeung et al., 2016, Han et al., 2017)和fNIRS(Yeung et al., 2019, Krishnamurthy et al., 2020)來檢查ASD兒童的前額葉皮層和抑制性控制。 我們還研究了一些干預措施,以改善需要特殊教育的兒童的行為問題,包括生活方式醫學方法和眼動追蹤計算機化培訓(Lee等人,2021)。  

 

我已獲得超過2300萬港元(作為主要研究者2100萬)的外部資金來進行我的研究。 我發表了一百多篇期刊文章和大約十本書。 我在《自然》、《科學報告》和《神經心理學》等國際知名期刊上發表過文章。 我的最高引用通訊作者文章是  933I ,我發表了66篇Q1論文和87篇第一作者或通訊作者論文。  2004年,我獲得了美國心理學會第40分部頒發的神經心理學早期職業獎。此外,我還被受幾個海外機構任命榮譽職位,包括聖地牙哥州立大學,加州大學聖地牙哥分校和密歇根大學安娜堡分校。 此外,我還曾擔任多家科學期刊的副主編或編輯委員會成員,包括《國際神經心理學會雜誌》、《神經心理學》、《阿爾茨海默病雜誌》、《臨床醫學雜誌》和《生活方式醫學》。此外,我還受邀在國際上舉辦研討會和研討會,包括哈佛大學和密歇根大學安娜堡分校。

 

除了研究,我還有很多興趣將我的知識傳授給社會。 我於1997年開發了香港文字

學習測試(HKLLT),這是香港一項經過生態驗證的語言記憶測試。 HKLLT自2006年以來一直向臨床專業人士和學者開放,並已被大多數公立醫院和政府機構以及一些研究機構使用超過15年。 我寫了9本可以讓公眾理解的書,並建立了一個YouTube頻道(觀看次數最高的視頻是七萬)。我於1998年創立香港神經心理學協會,以促進香港和亞洲的神經心理學。  此外,我還於2003年成立了慧能培訓協會,香港中文大學提供啟動資金支援,為有特殊教育的兒童提供我們的研究成果。